Development of Imaging Probes for Fracture Healing Response
Journal Title
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Issue Date
2020-04
Authors
Wah, Sa Lay
McCarthy, Jason, Advisor
Publisher
2020 Student Project Showcase, SUNY Polytechnic Institute
Keywords
bone fractures , acute phase response , bone restoration , high-resolution near-infrared fluorescence
Abstract
The five primary problems created by bone fractures are bleeding, infection, disproportionate strains, vascular discontinuity, and inability to bear weight. The body goes into the acute phase response (APR) in order to combat these injuries or trauma. The APR in fractures sees the formation of hydroxyapatite crystals, fibrin, and collagen fibers in bone restoration. In this project, imaging probes were made to enable high-resolution near-infrared fluorescence (NIRF) images of hydroxyapatite crystals, fibrin, and collagen fibers to monitor the bone healing response.