Redox control of senescence and age-related disease
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Authors
Chandrasekaran, Akshaya
Idelchik, Maria del Pilar Sosa
Melendez, J. Andrés
Issue Date
2017-03
Type
Article
Language
en_US
Keywords
oxidative stress , aging , senescence , senescence-associated secretory phenotype (SASP) , reactive oxygen species (ROS) , signaling network
Alternative Title
Redox Biology
Abstract
The signaling networks that drive the aging process, associated functional deterioration, and pathologies has captured the scientific community's attention for decades. While many theories exist to explain the aging process, the production of reactive oxygen species (ROS) provides a signaling link between engagement of cellular senescence and several age-associated pathologies. Cellular senescence has evolved to restrict tumor progression but the accompanying senescence-associated secretory phenotype (SASP) promotes pathogenic pathways. Here, we review known biological theories of aging and how ROS mechanistically control senescence and the aging process. We also describe the redox-regulated signaling networks controlling the SASP and its important role in driving age-related diseases. Finally, we discuss progress in designing therapeutic strategies that manipulate the cellular redox environment to restrict age-associated pathology.
Description
Citation
Chandrasekaran, A., Idelchick, M. D. P. S., & Melendez, J. A. (2017). Redox control of senescence and age-related disease. Redox Biology, 11, 91–102. doi:10.1016/j.redox.2016.11.005
Publisher
Redox Biology
License
Journal
Volume
Issue
PubMed ID
DOI
ISSN
2213-2317