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dc.contributor.authorCzajkowski, Hunter
dc.date.accessioned2022-11-10T21:03:14Z
dc.date.available2022-11-10T21:03:14Z
dc.date.issued2022
dc.identifier.urihttp://hdl.handle.net/1951/83078
dc.descriptionFODL Library Research Awards One of two 3rd-place winners for this year.en_US
dc.description.abstractIn this study the hypothetical protein Rho guanine nucleotide exchange factor 37, was analyzed through the use of four bioinformatics tools: SMART, GlobPlot, Phyre2, and BLAST. The universal protein data bank, Uniprot, was used to select the hypothetical protein, while the bioinformatics tools were used to investigate the hypothetical protein. SMART was used in the identification and analysis of the protein domains within the Rho guanine nucleotide exchange factor 37 protein sequence. GlobPlot was used to predict disorder and globular sequences of the hypothetical protein. Phyre2 was used to build a three dimensional model of Rho guanine nucleotide exchange factor 37, as well as determine the best matching known protein. Phyre concluded that Rho guanine nucleotide exchange factor 16 was the closest match, and used this data to produce a model with 100% confidence and 54% coverage for rho guanine nucleotide exchange factor 37. BLAST was also used to find the most similar match to Rho guanine nucleotide exchange factor 37, which produced a 98.8% to Rho guanine nucleotide factor 37 (Pan troglodytes). Using the bioinformatics tools, predictions regarding protein location and function were concluded. The predicted location of Rho guanine nucleotide exchange factor 37 is in the intracellular-cytosol, while it is predicted that Rho guanine nucleotide exchange factor 37 may act as a guanine nucleotide exchange factor which facilitates the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate. This study will overall investigate the hypothetical protein Rho guanine nucleotide exchange factor 37 through the use of the bioinformatics tools in order to best understand the hypothetical protein's function.en_US
dc.description.sponsorshipFriends of Drake Libraryen_US
dc.language.isoen_USen_US
dc.publisherSUNY Brockporten_US
dc.relation.ispartofseriesFriends of Drake Library-Library Research Awards;
dc.titleUsing Bioinformatics Tools to Study the Hypothetical Protein Rho Guanine Nucleotide Exchange Factor 37en_US
dc.typeArticleen_US


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