Research shows that ten to 15% of women will experience postpartum depression. Postpartum depression can impact a woman’s health and well being, her ability to bond with her baby, and her care giving with her other children. Postpartum depression impacts the health and development of children from infancy and throughout childhood, partner and other interpersonal relationships, and the stability of the family. There is a need to provide prevention and screening and to assist women with learning to identify early signs of postpartum depression, and understand where to seek help and support. This paper examines effective interventions for screening, prevention, and reduction of the severity of postpartum depression among women, particularly first time mothers. This information will help social workers and other healthcare professionals to more effectively intervene with mothers at risk of postpartum depression and assist new mothers with accessing the necessary services to promote the wellbeing of mother and child.