Bioactive glasses give rise to numerous applications in repairing bone injury as they can develop a calcium phosphate surface layer and support osteoblast adhesion and growth. This project focuses on determining the effect of amorphous /crystalline structure on the solubility of SiO2-TiO2-CaO-SrO/Na2O bioactive glasses. After pouring each glass, the glasses were grounded to fine powders which were then pressed to make discs. Half of discs were sintered to a crystalline state and the remaining half kept an amorphous state. X-ray Diffraction (XRD) was used to determine their amorphous /crystalline structure in order to relate the influence of the materials’ structure to bioactivity. The discs were then put into deionized water for 1, 7 and 30 days, when the water’s pH values were measured. The data indicated that the amorphous discs have a greater influence on the pH of the water. The 30-day amorphous samples resulted in a pH value change from 11.4-12.5, whereas crystalline samples ranged from 9.1-11.1. Amorphous and crystalline discs were immersed in Simulated Body Fluid (SBF) for 1, 7, 30 days. Scanning Electron Microscopy (SEM) was used to characterize the calcium phosphate surface layer deposited on the disc surfaces, which was more prevalent with the amorphous specimens.