When Gastrin Goes Awry: A Review of Normal Function and Role of Gastrin in Zollinger-Ellison Syndrome
MetadataShow full item record
Gastrin is a digestive hormone that acts on the neuroendocrine and parietal cells of the gastrointestinal tract to ultimately secrete gastric acid. Gastrin secretion begins even before food is consumed, as the mere anticipation of a meal can lead to a series of events ending in the creation of the gastric acid needed to breakdown foods. Not only does Gastrin support the digestion of foods, but it also stimulates growth, secretion, blood flow, and acts as a defense mechanism against bacteria in the gastrointestinal system. When the production of Gastrin becomes overt, major consequences like that of Zollinger Ellison Syndrome (ZES). ZES is an extremely rare disease occurring in people between the ages of 30-60.4 ZES is related to the uncontrolled secretion of gastrin due to the presence of certain pancreatic or duodenal tumors. The tumor stimulates the acid-secreting cells of the stomach to maximal activity, with consequent gastrointestinal mucosal ulceration.