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    Double emulsion electrospun nanofibers as a growth factor delivery vehicle for salivary gland regeneration

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    Double emulsion electrospun nanofibers_Final.pdf (1.442Mb)
    Date
    2017-08-29
    Author
    Foraida, Zahraa I.
    Sharikova, Anna
    Peerzada, Lubna N.
    Khmaladze, Alexander
    Larsen, Melinda
    Castracane, James
    Publisher
    SPIE Nanoscience + Engineering
    Metadata
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    Subject
    tissue regeneration
    nanofibers
    epidermal growth factor
    growth factor delivery
    Raman spectroscopy
    Abstract
    Sustained delivery of growth factors, proteins, drugs and other biologically active molecules is necessary for tissue engineering applications. Electrospun fibers are attractive tissue engineering scaffolds as they partially mimic the topography of the extracellular matrix (ECM). However, they do not provide continuous nourishment to the tissue. In search of a biomimetic scaffold for salivary gland tissue regeneration, we previously developed a blend nanofiber scaffold composed of the protein elastin and the synthetic polymer polylactic-co-glycolic acid (PLGA). The nanofiber scaffold promoted in vivo-like salivary epithelial cell tissue organization and apicobasal polarization. However, in order to enhance the salivary cell proliferation and biomimetic character of the scaffold, sustained growth factor delivery is needed. The composite nanofiber scaffold was optimized to act as a growth factor delivery system using epidermal growth factor (EGF) as a model protein. The nanofiber/EGF hybrid nanofibers were synthesized by double emulsion electrospinning where EGF is emulsified within a water/oil/water (w/o/w) double emulsion system. Successful incorporation of EGF was confirmed using Raman spectroscopy. EGF release profile was characterized using enzymelinked immunosorbent assay (ELIZA) of the EGF content. Double emulsion electrospinning resulted in slower release of EGF. We demonstrated the potential of the proposed double emulsion electrospun nanofiber scaffold for the delivery of growth factors and/or drugs for tissue engineering and pharmaceutical applications.
    URI
    http://hdl.handle.net/1951/69523
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    • SUNY Polytechnic Institute Faculty and Staff Research, Publications, and Creative Works [63]

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