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    • Student Research Showcase - April 12th and 13th, 2017
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    Taxotere as a Treatment for Ovarian Epithelial Carcinoma

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    Taxotere.4.pdf (405.7Kb)
    Date
    2017
    Author
    Hollfelder, Gabrielle
    LaRochelle, Sophie
    Neumann, Bernd
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    Description
    Epithelial ovarian cancer accounts for 90% of ovarian cancers, is the most lethal gynecological cancer, and the fifth-most common cause of cancer-related deaths in women in the United States(6). In 2016, there were an esitmated 22,280 new cases in the U.S. and the overall survival rate at 5 years is 46.2%(3). About 10% of cases are heriditary (4). Clinical trials have shown that the efficacy of more traditional platinum-based drugs are increased when combined with a taxane-based drug. Docetaxel, commercially Taxotere, is a taxane that has been in use since the mid-1990s and is used to treat many forms of cancer including ovarian but also; breast, lung, head and neck, gastric and prostrate carcinomas. Taxotere is derived from the needles of the European Yew tree (Taxus baccata) by a semisynthetic process(1)and like other taxane-based drugs, binds to microtubules during mitosis leading to apoptosis and cell death(2).
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    http://hdl.handle.net/1951/69159
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    • Student Research Showcase - April 12th and 13th, 2017 [12]

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