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dc.contributor.authorChandrasekaran, Akshaya
dc.contributor.authorIdelchik, Maria del Pilar Sosa
dc.contributor.authorMelendez, J. Andrés
dc.creator
dc.date.accessioned2017-05-01T19:41:29Z
dc.date.available2017-05-01T19:41:29Z
dc.date.issued2017-03
dc.identifier.citationChandrasekaran, A., Idelchick, M. D. P. S., & Melendez, J. A. (2017). Redox control of senescence and age-related disease. Redox Biology, 11, 91–102. doi:10.1016/j.redox.2016.11.005en_US
dc.identifier.issn2213-2317
dc.identifier.urihttp://hdl.handle.net/1951/69147
dc.description.abstractThe signaling networks that drive the aging process, associated functional deterioration, and pathologies has captured the scientific community's attention for decades. While many theories exist to explain the aging process, the production of reactive oxygen species (ROS) provides a signaling link between engagement of cellular senescence and several age-associated pathologies. Cellular senescence has evolved to restrict tumor progression but the accompanying senescence-associated secretory phenotype (SASP) promotes pathogenic pathways. Here, we review known biological theories of aging and how ROS mechanistically control senescence and the aging process. We also describe the redox-regulated signaling networks controlling the SASP and its important role in driving age-related diseases. Finally, we discuss progress in designing therapeutic strategies that manipulate the cellular redox environment to restrict age-associated pathology.en_US
dc.description.sponsorshipSUNY Polytechnic Institute, Colleges of Nanoscale Science and Engineering, 257 Fuller Road, Albany, NY 12203, USAen_US
dc.language.isoen_USen_US
dc.publisherRedox Biologyen_US
dc.subjectoxidative stressen_US
dc.subjectagingen_US
dc.subjectsenescenceen_US
dc.subjectsenescence-associated secretory phenotype (SASP)en_US
dc.subjectreactive oxygen species (ROS)en_US
dc.subjectsignaling networken_US
dc.titleRedox control of senescence and age-related diseaseen_US
dc.title.alternativeRedox Biologyen_US
dc.typeArticleen_US


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