The purpose of this study was to examine the effect of thigh compression wraps on 60 m sprint performance. Twenty-six physically active college students, seven men and nineteen women, were participants in the study. Participants completed two test sessions: participant’s thighs were compression wrapped in one test session, the treatment session, and not wrapped in the other test session, the control session. The results indicate that the use of compression wraps has a negative effect on sprint performance in women. The results differ from all other studies examining the effects of compression garments on sprint performance. Future studies should examine the effects of the use of compression wraps on performance in other activities.