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    Generation of Regionally Specified Dopaminergic Neural Cells from Induced Pluripotent Stem Cells

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    Date
    2016
    Author
    Aponte, Christina
    Jiang, Houbo, Dr.
    Feng, Jian, Dr.
    Metadata
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    Subject
    Parkinson's disease
    Regenerative medicine
    Nervous system--Degeneration
    Abstract
    Parkinson's disease is a neurodegenerative disease involving the malfunctioning and death of dopaminergic (DA) neurons. Due to the depletion of the neurons producing dopamine, there is a lack of the neurotransmitters responsible for communicating the signals necessary for movement and coordination. We found that differentiating induced pluripotent stem cells (iPSC) to DA neuron progenitors followed by transplantation into the rat brain may enable differentiation into DA neurons. After 3-4 months, we will extract the brain, mount it on a sequence of slides, and observe their differentiation. We have yet to produce consistent results. However, we will continue to repeat experimentation and review mechanics of the protocol.
    URI
    http://hdl.handle.net/1951/67574
    Collections
    • University at Buffalo [8]

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