The Mutation of Amyloid Precursor Protein and the Development of Alzheimer's Disease
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Alzheimer's Disease is a build of problematic plaques in the brain. These plaques are caused by the mutation of the amyloid precursor protein (APP). It is expressed in a wide range of different cell types including neurons. It can be proteolytically processed by beta and y-secretase. It has a copper binding domain and a central role in the development of Alzheimer's Disease. Amyloid precursor protein is cleaved by helper proteins which leads to the release of the Aβpeptide. If there is a single amino acid mutation in the Aβpeptide the material tangles, accumulates and creates plaques in the brain of Alzheimer's patients. APP is produced in large quantities and is metabolized quickly. APP is sorted in the endoplasmic reticulum and the Golgi, after sorting the protein is then shipped to the axons.