Inducing RNAi of dpy11 and bli-1 genes in C. elegans

Abstract

RNA interference (RNAi) is a biological process in which RNA molecules block gene expression, typically by causing the destruction of specific mRNA molecules. C. elegans is an excellent model system to study because many single gene mutations have been identified and the worms' transparency assist morphological observations. We are studying RNAi techniques by feeding E. coli to interrupt the dpy-11 and bli-1 genes in C. elegans, resulting in phenotype changes.