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dc.contributor.advisorCarpino, Nicken_US
dc.contributor.authorSivaram, Nithyaen_US
dc.contributor.otherDepartment of Biochemistry and Cell Biologyen_US
dc.date.accessioned2013-05-22T17:35:36Z
dc.date.available2013-05-22T17:35:36Z
dc.date.issued1-Dec-11en_US
dc.date.submitted11-Decen_US
dc.identifierSivaram_grad.sunysb_0771M_10815en_US
dc.identifier.urihttp://hdl.handle.net/1951/59864
dc.description30 pg.en_US
dc.description.abstractRegulatory T cells (Tregs) play a critical role in down-regulating immune responses to self antigens. Here we assess the significance of Sts-1 and Sts-2, two protein phosphatases that negatively regulate TCR signaling, in the development and maintenance of Tregs. We show that the number of splenic Tregs in vivo is elevated in the absence of Sts-1and Sts-2. We also found that Sts-1 and Sts-2 play a redundant role in TGF--mediated induction of Tregs in vitro. These data indicate that the Sts proteins are crucial for the maintenance of normal Treg populations in mice and also in TGF--mediated induction of Tregs in vitro.en_US
dc.description.sponsorshipStony Brook University Libraries. SBU Graduate School in Department of Biochemistry and Cell Biology. Charles Taber (Dean of Graduate School).en_US
dc.formatElectronic Resourceen_US
dc.language.isoen_USen_US
dc.publisherThe Graduate School, Stony Brook University: Stony Brook, NY.en_US
dc.subject.lcshImmunology--Biochemistryen_US
dc.subject.otherCD4+CD25+, Foxp3, Regulatory T cells, Sts-1, Sts-2, Tregen_US
dc.titleAn initial analysis of the role of Sts-1 and Sts-2 in the development of regulatory T cellsen_US
dc.typeThesisen_US
dc.description.advisorAdvisor(s): Carpino, Nick . Committee Member(s): Reich, Nancy.en_US
dc.mimetypeApplication/PDFen_US


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