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    A New Approach to the Synthesis of the Bicyclic Core of the Immunosuppressants SNF4435 C & SNF4435 D via Silicon Tethering

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    Dick_grad.sunysb_0771M_11232.pdf (756.5Kb)
    Date
    1-Dec-12
    Author
    Dick, Andrew Daniel
    Publisher
    The Graduate School, Stony Brook University: Stony Brook, NY.
    Metadata
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    Abstract
    The total synthesis of immunosuppressant and multidrug resistant (MDR) reversal agents SNF4435 C and SNF4435 D, isolated from the culture broth of an Okinawan strain of Streptomyces spectabilis in 2001, has been accomplished in a fourteen step process. The key reaction utilizes a Stille coupling en route to the final products. Considering the limitations of the Stille coupling, we are currently adjusting the procedure to allow for a new approach, which involves the use of a molecular tether to join the two precursor molecules. This thesis describes the synthesis of a new pair of precursors as well as our efforts toward linking said molecules together via an appropriate silicon bridge.
    Description
    40 pg.
    URI
    http://hdl.handle.net/1951/59629
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    • Stony Brook Theses & Dissertations [SBU] [1955]

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