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dc.contributor.authorPeter, Dinesh Amirtharajen_US
dc.contributor.otherDepartment of Biomedical Engineeringen_US
dc.date.accessioned2012-05-17T12:21:51Z
dc.date.available2012-05-17T12:21:51Z
dc.date.issued1-Aug-11en_US
dc.date.submittedAug-11en_US
dc.identifierPeter_grad.sunysb_0771M_10648.pdfen_US
dc.identifier.urihttp://hdl.handle.net/1951/56091
dc.description.abstractDrug-resistant hypertensive patients may be treated by mechanical stimulation of stretch-sensitive baroreceptors located in the sinus of carotid arteries. To evaluate the ability of custom devices to stretch the carotid sinus such that the induced stretch might trigger baroreceptors to increase action potential firing rate and thereby reduce hypertension, numerical simulations were conducted of several biomedical implant devices deployed in subject based carotid models. Two different carotid models were chosen to serve as virtual vascular environment for device deployment evaluation - a physiologic model and a diminutive non-physiologic model. Extravascular and endovascular device designs, custom built for the carotid models, were also chosen for evaluation. An augmented FSI with contact surface implemented methodology was used to conduct simulations. Results indicated that endovascular devices stretch carotid sinus more efficiently compared to extravascular devices. Effects of endovascular device deployment were evaluated on extreme carotid models and carotids under pathological conditions. These evaluations were conducted to test the limits of our numerical methodology and also to predict the response that such devices would elicit under various biological conditions. From the context of numerical simulations, endovascular devices consistently induced significant carotid sinus stretch, in all cases, thereby indicating that these devices might have a long lasting effect on reducing resistant hypertension.en_US
dc.description.sponsorshipStony Brook University Libraries. SBU Graduate School in Department of Biomedical Engineering. Lawrence Martin (Dean of Graduate School).en_US
dc.formatElectronic Resourceen_US
dc.language.isoen_USen_US
dc.publisherThe Graduate School, Stony Brook University: Stony Brook, NY.en_US
dc.subject.lcshBiomedical engineering -- Biomechanicsen_US
dc.subject.otherCarotid artery, Device, FSI, Hemodynamics, Hypertension, Wall stressen_US
dc.titleFluid Structure Interaction (FSI) for Evaluation of Biomedical Implant Devices for Novel Hypertension Treatment Therapyen_US
dc.typeThesisen_US
dc.description.advisorAdvisor(s): Danny Bluestein. Yi-Xian Qin. Committee Member(s): Helmut H. Strey; Nicos Labropoulos.en_US
dc.mimetypeApplication/PDFen_US


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