AbstractDrug-resistant hypertensive patients may be treated by mechanical stimulation of stretch-sensitive baroreceptors located in the sinus of carotid arteries. To evaluate the ability of custom devices to stretch the carotid sinus such that the induced stretch might trigger baroreceptors to increase action potential firing rate and thereby reduce hypertension, numerical simulations were conducted of several biomedical implant devices deployed in subject based carotid models. Two different carotid models were chosen to serve as virtual vascular environment for device deployment evaluation - a physiologic model and a diminutive non-physiologic model. Extravascular and endovascular device designs, custom built for the carotid models, were also chosen for evaluation. An augmented FSI with contact surface implemented methodology was used to conduct simulations. Results indicated that endovascular devices stretch carotid sinus more efficiently compared to extravascular devices. Effects of endovascular device deployment were evaluated on extreme carotid models and carotids under pathological conditions. These evaluations were conducted to test the limits of our numerical methodology and also to predict the response that such devices would elicit under various biological conditions. From the context of numerical simulations, endovascular devices consistently induced significant carotid sinus stretch, in all cases, thereby indicating that these devices might have a long lasting effect on reducing resistant hypertension.