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Nanostructured Hydrogel Implants for Post Lumpectomy Patients

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dc.contributor.author Elluru, Mahati en_US
dc.contributor.other Department of Chemistry en_US
dc.date.accessioned 2012-05-17T12:20:32Z
dc.date.available 2012-05-17T12:20:32Z
dc.date.issued 1-May-11 en_US
dc.date.submitted May-11 en_US
dc.identifier Elluru_grad.sunysb_0771M_10538.pdf en_US
dc.identifier.uri http://hdl.handle.net/1951/55991
dc.description.abstract Breast cancer patients encounter several complications while undergoing the lumpectomy procedure. Modified Pluronics possessing the ability to crosslink can function as implants for post lumpectomy patients. In this project, the tri-block copolymer, Pluronic F127, a member of the Pluronics copolymers, has been chemically modified by introducing vinyl groups at the terminal ends of the polymer chain. The modified copolymer is cross-linkable by UV irradiation and forms a soft, tough gel with mechanical properties comparable to native human breast tissue. The polymer can be engineered to replicate the physical and mechanical properties of the human breast tissue. This can be done by varying the block length and block ratio as well as the extent of cross-linking, which can be achieved by altering the irradiation time, the polymer concentration and the concentration of the photo-initiator. The gel possesses both hydrophilic and hydrophobic domains that can be utilized to incorporate additional agents as required. The constituents of the gel and the cross-linked gel have been tested for cytotoxicity with the preadipocyte cell line. With the incorporation of growth factors and other proteins, the cross-linked Pluronics have a potential to be used as a scaffold for regeneration of the native breast tissue while undergoing in vivo degradation. en_US
dc.description.sponsorship Stony Brook University Libraries. SBU Graduate School in Department of Chemistry. Lawrence Martin (Dean of Graduate School). en_US
dc.format Electronic Resource en_US
dc.language.iso en_US en_US
dc.publisher The Graduate School, Stony Brook University: Stony Brook, NY. en_US
dc.subject.lcsh -- Biomedical Engineering en_US
dc.subject.other Cross-linking, Hydrogels, Implant, Pluronics, Polymers, Radiation en_US
dc.title Nanostructured Hydrogel Implants for Post Lumpectomy Patients en_US
dc.type Thesis en_US
dc.description.advisor Advisor(s): Benjamin Chu. Benjamin Hsiao. Committee Member(s): Robert B. Grubbs; Peter J. Tonge. en_US
dc.mimetype Application/PDF en_US

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