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The Specificity of Vesicle Trafficking during Prospore Membrane Formation in Yeast

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dc.contributor.advisor Zador, Anthony M.; Turner, Glenn en_US
dc.contributor.author Yang, Hui-Ju en_US
dc.contributor.other Department of Molecular and Cellular Biology en_US
dc.date.accessioned 2012-05-15T18:07:24Z
dc.date.available 2012-05-15T18:07:24Z
dc.date.issued 1-Dec-10 en_US
dc.date.submitted Dec-10 en_US
dc.identifier Yang_grad.sunysb_0771E_10372.pdf en_US
dc.identifier.uri http://hdl.handle.net/1951/55680
dc.description.abstract This research focuses on the production of new plasma membranes during gametogenesis in yeast. The initiation of these membranes is started by vesicle fusion at spindle pole bodies (SPBs) during Meiosis II. I have asked how these vesicles specifically fuse at SPBs but not at other locations, and demonstrated that binding interactions between soluble NSF attachment protein receptors (SNAREs) confer one layer of specificity to vesicle fusion at SPBs. Furthermore, I showed that SPBs can actively regulate a Rab GTPase, suggesting a role for SPBs in vesicle docking. My work highlights the ancestral dual roles of centrioles in microtubule organization and membrane nucleation, the latter of which is required for cilium formation in mammalian cells. en_US
dc.description.sponsorship Stony Brook University Libraries. SBU Graduate School in Department of Molecular and Cellular Biology. Lawrence Martin (Dean of Graduate School). en_US
dc.format Electronic Resource en_US
dc.language.iso en_US en_US
dc.publisher The Graduate School, Stony Brook University: Stony Brook, NY. en_US
dc.subject.lcsh Molecular Biology -- Cellular Biology en_US
dc.subject.other centriole, prospore membrane, Sec2, SNARE, spindle pole body en_US
dc.title The Specificity of Vesicle Trafficking during Prospore Membrane Formation in Yeast en_US
dc.type Dissertation en_US
dc.description.advisor Advisor(s): Aaron Neiman. Committee Member(s): Nancy Hollingsworth; Deborah Brown; Neta Dean; Michael Frohman; Wei Guo en_US
dc.mimetype Application/PDF en_US
dc.embargo.release 8/1/12 en_US
dc.embargo.period 2 Years en_US

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