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X-ray Diffraction Microscopy: Computational Methods and Scanning-type Experiments

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dc.contributor.advisor Jacobsen, Chris J. en_US
dc.contributor.author Steinbrener, Jan Felix en_US
dc.contributor.other Department of Physics en_US
dc.date.accessioned 2012-05-15T18:06:55Z
dc.date.available 2012-05-15T18:06:55Z
dc.date.issued 1-Aug-10 en_US
dc.date.submitted Aug-10 en_US
dc.identifier Steinbrener_grad.sunysb_0771E_10184.pdf en_US
dc.identifier.uri http://hdl.handle.net/1951/55634
dc.description.abstract X-ray Diffraction Microscopy (XDM) has been gaining in popularity for nanoscale imaging of biological and material science samples. Its high penetration depth (compared to electron microscopy) and its good dose efficiency (compared to its lens-based X-ray alternative) make it uniquely suited for imaging whole biological specimens, where radiation damage is a concern. Despite these advantages, XDM is still far from being a routine imaging tool. This is due to the computational challenge of reconstructing an image from recorded diffraction intensities as well as difficult-to-satisfy experimental requirements. I address these challenges by improving on the computational methods and by implementing a more reliable experimental geometry for our existing diffraction microscope at the Advanced Light Source, Lawrence Berkeley Lab. First, a software library has been developed that streamlines the post-experiment processing of data and that improves on an important aspect of data analysis. Results will be shown that illustrate the collective improvement to the reconstruction process. A modified version of a tool commonly used to assess the consistency of reconstructions is proposed and criteria of its validity are derived. Results show that it has improved utility for judging reconstruction quality. Second, a scanning-type experimental setup has been implemented for our existing diffraction microscope. Several possible geometries are discussed and preliminary results from recent experimental data are shown. en_US
dc.description.sponsorship Stony Brook University Libraries. SBU Graduate School in Department of Physics. Lawrence Martin (Dean of Graduate School). en_US
dc.format Electronic Resource en_US
dc.language.iso en_US en_US
dc.publisher The Graduate School, Stony Brook University: Stony Brook, NY. en_US
dc.subject.lcsh Biophysics, General Physics, Optics -- Physics, Radiation en_US
dc.subject.other Coherent diffractive imaging, X-ray diffraction microscopy en_US
dc.title X-ray Diffraction Microscopy: Computational Methods and Scanning-type Experiments en_US
dc.type Dissertation en_US
dc.description.advisor Advisor(s): Chris J. Jacobsen. Committee Member(s): Alexandre G. Abanov; Anand Sivaramakrishnan; Hanfei Yan. en_US
dc.mimetype Application/PDF en_US

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