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Roles of Calcium Signaling and Protein Kinase C Activation in Mediating Receptor Control of Corneal Epithelial Renewal

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dc.contributor.author Zhang, Fan
dc.date.accessioned 2007-06-26T20:01:51Z
dc.date.available 2007-06-26T20:01:51Z
dc.date.issued 2007-06-26T20:01:51Z
dc.identifier.uri http://hdl.handle.net/1951/41605
dc.description.abstract Epidermal growth factor, EGF, is one of the essential growth factors that stimulates injury-induced corneal epithelial healing rates. Cell signaling contributors mediating this response include capacitative calcium entry (CCE) activation and protein kinase C (PKC) isoform stimulation. This study shows in human corneal epithelial cells, HCEC, that CCE is preferentially activated by the PKC isoforms  and . Moreover such activation requires increases in plasma membrane Ca2+ influx through store-operated channels. Therefore, EGF-induced stimulation of cell proliferation and migration may depend on unique effects mediated by six different PKC isoforms identified in HCEC. TRPV1 is a vanilloid subtype of the transient receptor potential protein superfamily. This isoform is a subunit of a non-selective cation channel mediating downstream responses to heat, low pH, or noxious stimuli. TRPV1 expression has been recently described in some epithelial tissues and induces proinflammatory cytokine release through mitogen-activated protein kinase (MAPK) superfamily stimulation. This study describes in HCEC the signaling pathways mediating TRPV1-induced increases in proinflammatory cytokine release. It suggests that epithelial TRPV1 receptor activation by noxious stimuli contributes in-vivo to mounting proinflammatory reactions. en
dc.description.sponsorship State University of New York, State College of Optometry en
dc.format.extent 11172864 bytes
dc.format.mimetype application/msword
dc.language.iso en_US en
dc.subject corneal epithelium en
dc.subject calcium signaling en
dc.subject epidermal growth factor en
dc.title Roles of Calcium Signaling and Protein Kinase C Activation in Mediating Receptor Control of Corneal Epithelial Renewal en
dc.type Thesis en


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