Now showing items 1-3 of 3

    • A study of cell death pathways and innate immunity in cancer chemotherapy 

      Guerriero, Jennifer Lynn (The Graduate School, Stony Brook University: Stony Brook, NY., 1-Aug-10)
      Dysregulation of apoptosis is associated with the development of human cancer and resistance to anti-cancer therapy. The ultimate goal of cancer treatment is to selectively induce cancer cell death and to overcome drug ...
    • Study of Phosphatidylinositol 3-Kinase in the Regulation of Autophagy 

      Dou, Zhixun (The Graduate School, Stony Brook University: Stony Brook, NY., 1-Aug-12)
      Autophagy is an evolutionarily conserved membrane trafficking process that maintains cell and tissue homeostasis. Autophagy plays essential roles in response to starvation and stress, and is involved in organelle homeostasis. ...
    • Two p53 mutants display differential gain-of-function effects on tumorigenesis in vivo 

      Hanel, Walter George (The Graduate School, Stony Brook University: Stony Brook, NY., 1-Aug-12)
      p53 is a transcription factor which promotes cell cycle arrest, DNA damage repair, and apoptosis in the presence of DNA damage or oncogenic signaling. It is mutated in more than half of all human cancers demonstrating ...