Browsing Stony Brook Theses & Dissertations [SBU] by Subject "Cancer chemotherapy, DNA repair, Interstrand Crosslinks, Nitrogen mustard, Reductive amination"

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Nitrogen Mustard Reloaded: Synthesis and Structural Studies of DNA Interstrand Crosslinks

Guainazzi, Angelo (The Graduate School, Stony Brook University: Stony Brook, NY., 1-Aug-10)

Many of the drugs used in cancer chemotherapy target DNA to kill malignant cells. Some of them form DNA interstrand crosslinks (ICLs), which are extremely cytotoxic lesions that block essential metabolic process such as ...