Browsing Stony Brook Theses & Dissertations [SBU] by Subject "BBB, CCR2, ICH, MCP1, microglia, TJP"

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Plasmin-Mediated Cleavage of Monocyte Chemoattractant Protein-1 (MCP1) Affects Its Biological Activities

Yao, Yao (The Graduate School, Stony Brook University: Stony Brook, NY., 1-May-11)

Monocyte chemoattractant protein-1 (MCP1) is a potent chemokine for monocytes and microglia. Previous studies in our lab showed that plasmin cleaved mouse MCP1 at lysine (K) 104 and the truncated MCP1 (N terminal fragment ...