Cdc7, a highly conserved serine/threonine kinase, is essential for DNA replication in mitotically dividing cells. Previous work using temperature-sensitive mutants of CDC7 demonstrated a requirement for this kinase in ...

Polypeptide 2C<super>ATPase</super> is one of the most thoroughly studied but least understood proteins in the life cycle of poliovirus. Within the protein, multiple functional domains, important for uncoating, host cell ...

There is increasing evidence that cancers develop as aberrant tissues with co-evolving tumor and surrounding non-malignant cells rather than from a single aberrant cell that has undergone multiple genetic alterations. As ...

This dissertation investigated whether the internal bone morphology of the distal tibia and talus may help to further clarify the controversial mosaics of external morphological traits previously found in fossil hominin ...

Intergroup encounters provide dramatic examples of cooperative behavior, in which unrelated individuals may coordinate aggression when mutual benefits arise from defending access to resources. While between-group competition ...

The ability of interferons to protect cells from viral infection depends on the activation of multiple interferon-stimulated genes that together induce an anti-viral state. One of the genes is Interferon Stimulated Gene ...