Browsing Stony Brook Theses & Dissertations [SBU] by Title
Now showing items 1047-1066 of 1961
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Mechanism and Inhibition of Bacterial Enoyl-ACP Reductases: Towards Novel Antibacterial Drugs
(The Graduate School, Stony Brook University: Stony Brook, NY., 1-May-10)Resistance to existing antimicrobial agents is a global threat to human health care, and new drugs with novel mechanisms of action are required in order to keep pace with the emergence of drug resistant pathogens. The ... -
Mechanism and Inhibition Studies of Enoyl-ACP Reductases and Dihydroxynaphthoyl-CoA Synthase in Pathogenic Bacteria
(The Graduate School, Stony Brook University: Stony Brook, NY., 1-Aug-11)Resistance to existing antimicrobial agents is a global threat to human health care, and new drugs with novel mechanisms of action are required in order to keep pace with the emergence of drug resistant pathogens. The ... -
Mechanism and Inhibition Studies of MenE MbtI and MenF Three Potential Drug Targets against Mycobacterium Tuberculosis and Staphylococcus aureus
(The Graduate School, Stony Brook University: Stony Brook, NY., 1-Aug-10)A detailed understanding of the catalytic mechanism of enzyme drug targets is required to guide structure-based drug discovery. In my thesis research I have primarily focused on the catalytic mechanism and inhibition of ... -
The Mechanism of Complement-Independent Bactericidal Antibodies Against Borrelia
(The Graduate School, Stony Brook University: Stony Brook, NY., 2009-05-01) -
Mechanism of Maintenance of Cellular Senescence
(The Graduate School, Stony Brook University: Stony Brook, NY., 2007-12-01) -
Mechanism of Reversion of Calcium-Induced Differentiation in Keratinocytes
(The Graduate School, Stony Brook University: Stony Brook, NY., 1-Dec-10)Terminal differentiation defines cells that permanently exit the cell cycle in the process of specialization. Under some circumstances, however, this process is reversed as demonstrated by the ability of differentiated ... -
Mechanism of YopJ-Induced Cell Death and Capase-1 Activation in Macrophages Infected with Yersinia
(The Graduate School, Stony Brook University: Stony Brook, NY., 1-Dec-11)Pathogenic Yersinia species encode a Type III Secretion System (T3SS) that translocates a group of effectors termed as Yersinia outer proteins (Yops) into target cells to disrupt eukaryotic host signaling pathways. YopJ ... -
MECHANISMS AND SPATIOTEMPORAL EVOLUTION OF INTRACELLULAR Ca2+ ALTERNANS IN CARDIAC TISSUE
(The Graduate School, Stony Brook University: Stony Brook, NY., 1-May-12)Instabilities in cardiac repolarization, presented as T-wave alternans (TWA) in the ECG, are a known precursor of re-entrant cardiac arrhythmias, e.g. ventricular tachycardia (VT) and ventricular fibrillation (VF). ... -
Mechanisms Controlling Variability in Long Island Sound
(2011-09-13) -
Mechanisms of Anxiety-Depression Co-Occurrence
(The Graduate School, Stony Brook University: Stony Brook, NY., 1-May-10)Anxiety and depression are highly comorbid, and mechanisms of their co-occurrence remain largely unclear. Several longitudinal studies suggest that anxiety disorders tend to temporally precede depression, but few comorbidity ... -
Mechanisms of Endoplasmic Reticulum Stress-Induced Cell Death
(The Graduate School, Stony Brook University: Stony Brook, NY., 1-May-11)In cells, incorrectly folded proteins or compromised protein turnover induce cellular stress known as endoplasmic reticulum (ER) stress. Significantly, ER stress plays an important role in numerous physiological and ... -
Mechanisms of growth and sex determination in the Atlantic silverside, Menidia menidia, and the spatial scale of local adaptation
(The Graduate School, Stony Brook University: Stony Brook, NY., 1-Aug-10)Local adaptation in widely-dispersed marine species may result from strong selection on multiple life history traits that differ among populations. This results in unique sets of traits that maximize fitness of individuals ... -
The Mechanisms of Inhibition of Fertilization and Activation of Development by Fertilin [beta] Derived Oligopeptide Polymers
(The Graduate School, Stony Brook University: Stony Brook, NY., 2008-12-01) -
Mechanisms Underlying Angiotensin II Type 1 Receptor Mediated Electrical Remodeling in Left Ventricular Myocytes
(The Graduate School, Stony Brook University: Stony Brook, NY., 1-Aug-11)The angiotensin II type 1 (AT<sub>1</sub>) receptor is a G protein coupled receptor that is highly active in various cardiac disease states. Both the AT<sub>1</sub> receptor and its primary effector, angiotensin II (A2), ... -
Mechanistic Studies of the Photoactive Protein AppA
(The Graduate School, Stony Brook University: Stony Brook, NY., 1-May-12)The blue light using flavin (BLUF) domain proteins are a novel class of photosensors that bind flavin noncovalently in order to sense and respond to high intensity blue (450 nm) light. The transcriptional antirepressor ... -
Medically-derived I-131 as a tracer in aquatic environments
(The Graduate School, Stony Brook University: Stony Brook, NY., 1-Aug-11)¶Medically-derived <super>131</super>I (half-life = 8.04 d) has been measured in aquatic environments receiving sewage effluent discharges, yet few published data exist for the radioisotope in sewage effluent; most ...
