Browsing by Author "Guainazzi, Angelo"
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Nitrogen Mustard Reloaded: Synthesis and Structural Studies of DNA Interstrand Crosslinks
Guainazzi, Angelo (The Graduate School, Stony Brook University: Stony Brook, NY., 1-Aug-10)Many of the drugs used in cancer chemotherapy target DNA to kill malignant cells. Some of them form DNA interstrand crosslinks (ICLs), which are extremely cytotoxic lesions that block essential metabolic process such as ...