The formation of amyloid fibrils plays a role in a wide range of diseasescollectively known as amyloidosis. Amyloid fibrils are formed when peptides or proteinsmisfold and deposit in tissues and organs. These deposits ...

Drug addiction is primarily a disease of the brain's reward system. The resulting compromise in reward sensitivity traces its roots to the striatal reward circuitry, where excess dopamine is released by the acute administration ...

Mammalian inositol-specific phospholipase Cβ1 (PLCβ1) is activated by Gαq subunits on the plasma membrane where it catalyzes hydrolysis of the minor membrane phosphatidylinositol 4,5 bisphosphate. While ...

M. tuberculosis has a cholesterol oxidizing activity that initiates sterol metabolism, which may be related to its virulence. Rv3409c of M. tuberculosis H37Rv was annotated as a putative cholesterol oxidase, an enzyme that ...

Matrix metalloproteinases (MMPs) play an important role in cancer progression by degrading extracellular matrix components, promoting tumor cell migration, and thus enhancing tumor metastasis. Several generations of ...