Epithelial ovarian cancer is the leading cause of death from gynecological malignancies. Currently platinum-based chemotherapy (such as cisplatin or carboplatin), coupled with a taxane based drug such as paclitaxel is the ...

The spatial and temporal control of gene expression is key to generation of specific cellular fates during development. Studies of the transcriptional repressor REST/NRSF (RE1 Silencing Transcription factor/Neural Restrictive ...

Cancer cells preferentially metabolize glucose by aerobic glycolysis, characterized by increased lactate production. This distinctive metabolism involves expression of the embryonic M2 isozyme of pyruvate kinase, in contrast ...

Myelin is essential for proper human neurophysiology, but the precise molecular mechanisms underlying the myelination process remain poorly understood. One potential effector molecule, the b1 integrin, has been suggested ...

Gap junctions are intercellular channels formed by connexin (Cx) proteins which create a pathway for the transport of ions and small metabolites between two adjacent cells that are in contact. In individual cells connexin ...